The South African National Bioinformatics Institute (SANBI) is based at the University of Western Cape (UWC). SANBI has state of the art IT, server and High-Performance Computing (HPC) infrastructure and training facilities. SANBI is dedicated to capacity development in Bioinformatics and its applications, offering undergraduate and postgraduate training programmes including MSc, PhD and Post-Doctoral with impressive Dell cluster with 232 CPU cores and 1952 GB of RAM and, also provides dedicated Virtual Machine Infrastructure through its own cloud platform servers providing 64 CPUs and 340 GB of RAM to support research. The SANBI research team includes groups in the areas of genetic diversity, gene regulation, cancer, sleeping sickness, the Human Immunodeficiency Virus (HIV) and Precision medicine. SANBI is funded by several organisations including the South African Medical Research Council, the National Research Foundation of South Africa, the Claude Leon Foundation, the John E. Fogarty Foundation for International Health at the National Institutes of Health, and the European Commission. SANBI maintains collaborations with institutes and laboratories internationally: at Harvard University, Oxford University, Cambridge University, Stanford University, the Pasteur Institute, the RIKEN institute, the Allen Institute for Brain Science, the Institut National de la Santé et de la Recherche Médicale and the European Bioinformatics Institute amongst others. Amongst others, SANBI is also spear heading LIMS implementation and training of open source Baobab LIMS for biobanks and biorepositories in Africa as part of the Horizon 2020 funded project, B3Africa. The head of SANBI, Prof. Alan Christoffels is the Director of South African Medical Research Council (SAMRC) Bioinformatics Unit and Research Chair in Bioinformatics and Health Genomics for Department of Science and Technology (DST) of South African government and National Research Foundation (NRF), driving various PM Research initiatives within SANBI. In addition, UWC, also has a Precision Medicine unit at the Department of Biotechnology within the faculty of Natural Sciences. SANBI is also a new node of H3ABioNet since 2019 as part of H3Africa funded by the NIH, headed by Dr. Kumuthini tackling various aspects of PM implementation in Africa from increasing the value to genomics and phenomic data for enabling effective Machine Learning and translation of research into practice.