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Course Overview: This interactive workshop will provide an overview of data management, analysis and submission for H3Africa projects. It also provides an opportunity for Data Support Working Group members, who represent the H3Africa projects to engage with H3ABioNet and discuss their needs.
Intended Audience: This workshop is aimed at Data Support Working Group members who should be the H3Africa project data managers, data analysts or bioinformaticians. It is important that the attendees have knowledge of the data being generated by their H3Africa projects and information about the project’s data analysis plan.
Keywords: Data handling, Ontologies, Genomics, Nucleic acid analysis
Language: English
Skill level: Intermediate
Type of training: face-to-face / in person
Credential awarded: none
Workshop dates: 12th May 2016
Venue: Ocean Room, Radisson Blu Hotel, Dakar, Senegal
Workshop organisers and sponsors: H3ABioNet, NIH Common Fund
Workshop trainers and support: Nicola Mulder, Sumir Panji, Ayton Meintjes, Scott Hazelhurst, Fourie Joubert, Alia Benkahla and Faisal Fadlemola.
Syllabus: Participants will discuss their current data plans and challenges. Lectures will be given on Clinical data collection & storage, overview of GWAS/NGS/microbiome processing, downstream analysis (Variant annotation, meta-analysis, structure, ancGWAS), Data transfer considerations, security, data processing options, and H3Africa Archive and EGA submission. This will be followed by discussion on developing data management plans (with reference to the article: Michener WK (2015) Ten Simple Rules for Creating a Good Data Management Plan. PLoS Comput Biol 11(10): e1004525), and interactive sessions discussing specific projects.
Prerequisites: Participants should complete the survey at: H3Africa Data Support workshop planning survey - Senegal 2016. One survey needs to be completed per H3Africa project.
Objectives:
Workshop limitations: This workshop will provide a foundation for continued learning in the handling of H3Africa project data. It will not make one an expert in specific data analysis pipelines.
Workshop Program
Time | Topic |
8:30 am | Registration |
9:00 am | Welcome and Participant introductions (Nicky) |
9:10 am | Discussion in groups on workshop expectations and report back (All) |
9:30 am | Clinical data storage (Freedom) & CRF harmonization (Alia) |
10:00 am | Overview of NGS data analysis pipeline for human genomes & microbiomes (Fourie) |
10:30 am | Tea break |
11:00 am | Overview of GWAS data analysis pipelines (Scott) |
11:30 am | Down stream analysis – varian tannotation and analysis (Nicky) |
11:50 am | Data processing options - Cloud & Galaxy (Scott & Fourie) |
12:20 pm | Data transfer, storage and security considerations (Ayton) |
12:40 pm | H3Africa Archive and EGA submission (Ayton) |
1:00pm | Lunch break |
2:00pm | Developing a Data Management plan (Sumir,Faisal) |
2:20pm | Group sessions on data management plans (Break-out sessions) |
3:00pm | Tea Break |
3:30pm | Report back on data management sessions (group leads) |
4:00pm | Group sessionson data analysis requirements(Break-outsessions) |
4:40pm | Report back on data analysis break-out sessions (group leads) |
5:00pm | Workshop End |
Training Materials Availability:
Training materials for this course are available as a single downloadable archive here: https://doi.org/10.25375/uct.19130012. Should you re-use any of these materials, please ensure that both the author/s of the material AND H3ABioNet are clearly credited.
Workshop dates: Sunday, 8 October 2017 [post doc/ early career scientist stream] (08:30-17:15); Monday, 9 October 2017 [student stream] (08:30-17:00)
Venue: Ocean Room, Radisson Blu Hotel, Dakar, Senegal
Workshop organisers and sponsors: H3ABioNet, NIH Common Fund
Workshop trainers and support: Nicola Mulder, Sumir Panji, Ayton Meintjes, Scott Hazelhurst, Fourie Joubert, Alia Benkahla and Faisal Fadlemola.
Course Overview: This interactive workshop will provide an overview of data management, analysis and submission for H3Africa projects. It also provides an opportunity for Data Support Working Group members, who represent the H3Africa projects to engage with H3ABioNet and discuss their needs.
Intended Audience: This workshop is aimed at Data Support Working Group members who should be the H3Africa project data managers, data analysts or bioinformaticians. It is important that the attendees have knowledge of the data being generated by their H3Africa projects and information about the project’s data analysis plan.
Syllabus: Participants will discuss their current data plans and challenges. Lectures will be given on Clinical data collection & storage, overview of GWAS/NGS/microbiome processing, downstream analysis (Variant annotation, meta-analysis, structure, ancGWAS), Data transfer considerations, security, data processing options, and H3Africa Archive and EGA submission. This will be followed by discussion on developing data management plans (with reference to the article: Michener WK (2015) Ten Simple Rules for Creating a Good Data Management Plan. PLoS Comput Biol 11(10): e1004525), and interactive sessions discussing specific projects.
Prerequisites: Participants should complete the survey at: H3Africa Data Support workshop planning survey - Senegal 2016. One survey needs to be completed per H3Africa project.
Objectives:
Workshop limitations: This workshop will provide a foundation for continued learning in the handling of H3Africa project data. It will not make one an expert in specific data analysis pipelines.
Workshop Program
DMWS2016 - 01 - security.pdf | [ ] | 1776 Kb |
DMWS2016 - 02 - archive.pdf | [ ] | 1315 Kb |
Course Overview: The goal of the H3ABioNet Data Management workshop is to prepare H3Africa researchers for management of their data, including knowing what data to collect, what file formats, etc. to use. The course will present options for setting up and storing patient data, discuss the EGA requirements to ensure the researchers collect all the necessary data, and determine the computational needs for storing, processing and mining of the data.
Keywords: Data handling, Genomics, Genetics, Biological data resources, Protein analysis, Sequence analysis, Systems Biology, Structure Analysis
Language: English
Skill level: Advanced
Type of training: face-to-face / in person
Credential awarded: none
Proposed workshop outcomes: The outcome will be that researchers have a better idea of what to expect when their data is generated and how to manage this data effectively.
Proposed workshop relevance: Most of the H3Africa projects are in the stage of data generation and it is important that they know as soon as possible what is involved in data collection and management.
Target audience of the proposed workshop: Data managers from the H3Africa research projects.
Applications are now closed.
Programme:
Presentation |
Topic |
Description (Recorded Lecture) |
Speaker (Slides) |
1 |
H3Africa data access policy |
Detail the H3Africa data sharing and access policy, and H3ABioNet's role |
|
2 |
Data consent |
||
3 |
LIMS systems |
||
4 |
LIMS systems |
||
5 |
LIMS systems |
||
6 |
LIMS systems |
Freedom Mukomana5 |
|
7 |
Patient databases |
OpenMRS |
|
8 |
Patient databases |
||
9 |
EBI Variation Resources |
||
10 |
EGA and SRA |
EGA overview,process of submission (NGS and GWAS), data required, metadata, formats etc. |
Ilkka Lappalainen6 |
11 |
EVA |
Ilkka Lappalainen6 |
|
12 |
DGVA |
Ilkka Lappalainen6 |
|
13 |
H3Africa phenotypes |
||
14 |
H3ABioNet archive solution |
||
15 |
GWAS |
||
16 |
GWAS |
||
17 |
GWAS |
||
18 |
GWAS |
||
19 |
NGS data |
||
20 |
NGS data |
||
21 |
NGS data |
||
22 |
GWAS Downstream analysis |
||
23 |
Public datasets |
Where to find them, Ensembl, USCS, extracting data using Galaxy, BioMarts |
|
24 |
Data management |
1: University of Cape Town, 2: BIKA laboratories, 3: South African National Bioinformatics Institute, 4: Jembi Health Systems, 5: University of the Witwatersrand, 6: European Genome-phenome Archive, 7: University of Illinois.
Group picture of participants and speakers for the H3ABioNet Data Management 2014 workshop.
Training Materials Availability:
Training materials for this course are available as a single downloadable archive here: https://doi.org/10.25375/uct.19130024. Should you re-use any of these materials, please ensure that both the author/s of the material AND H3ABioNet are clearly credited.
Tools and Services
Communication